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BOOK SUMMARY :

Pharmacokinetics in clinical practice i concepts milo gibaldi phd gerhard levy pharmd sbimportant concepts of pharmacokinetics such as the biologic half life clearance and bioavailability of drugs can be utilized to describe and pre dict the time course ofdrug concentrations in plasma as a function dose and frequencyof drugadministration in quantitativeterms theycan serve to pharmacokinetics in clinical practice i concepts jama 1976 apr 26235171864 7 authors m gibaldi g levy pmid 946488 abstract important concepts of pharmacokinetics such as the biologic half life clearance and bioavailability of drugs can be utilized to describe and predict the time course of drug concentrations in plasma as a a clinical pharmacokinetics service can monitor drug concentrations in biologic fluids design individualized drug dosing regimens and carry out pharmacokinetic diagnostic work ups to help determine the reasons for a patients unusual response to drug therapy jama 2351987 1992 1976therefore the application of pharmacokinetics to dosage regimen design must be coordinated with proper clinical evaluation of the patient for certain critical dose drugs monitoring both the patient and drug regimen is important for proper efficacythe pharmacokinetic concepts introduced and defined in a preceding article are now applied to the management of drug therapy for the individual patient the factors that affect the time course of drug concentrations in plasma produced by repetitive administration include the dosing rate total clearance biologic half life and systemic availability of the drug a clinical pharmacokinetics

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